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Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.

Abstract:

Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease severity and transmission. Quantitatively partitioning the relative roles of these effects through time is challenging. Using data from rodent malaria, we estimated the effective propagation number, which reflects the relative importance of contrasting within-host control mechanisms through time and is sensitive to the inoculating parasite do...

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Publication status:
Published

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Publisher copy:
10.1126/science.1204588

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Journal:
Science (New York, N.Y.) More from this journal
Volume:
333
Issue:
6045
Pages:
984-988
Publication date:
2011-08-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075

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