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The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum.

Abstract:

Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC₅₀) of P. vivax and P. falciparum to artesunate and chloroquine relative to results with the paired leukocyte-free treatment. Although leukocyte removal is not an essential requirement for the conduct of ex vivo assays, its use has important implications for the inte...

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Publication status:
Published

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Publisher copy:
10.1128/aac.01103-10

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Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
55
Issue:
3
Pages:
1300-1304
Publication date:
2011-03-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Keywords:
Pubs id:
pubs:110187
UUID:
uuid:d2f2f009-e781-4f47-9505-1e8788d85b67
Local pid:
pubs:110187
Source identifiers:
110187
Deposit date:
2012-12-19

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