Connexin43 transduction of skeletal myoblasts improves their electrical coupling with cardiac myocytes
Background: Organ transplantation is presently often the only avai lable option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from auto logous skeletal myoblasts is a promising novel therapeutic strategy. The functionality of skeletal mu scle cells in the heart milieu is, howeve r, limited because of their inability to integrate electrically and mechanically into the myocardium. Therefore, in pursu it of improved cardiac integration of skeletal muscle gr...Expand abstract
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© 2006 Tolmachov et al; licensee BioMed Central Ltd.
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