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Connexin43 transduction of skeletal myoblasts improves their electrical coupling with cardiac myocytes

Abstract:

Background: Organ transplantation is presently often the only avai lable option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from auto logous skeletal myoblasts is a promising novel therapeutic strategy. The functionality of skeletal mu scle cells in the heart milieu is, howeve r, limited because of their inability to integrate electrically and mechanically into the myocardium. Therefore, in pursu it of improved cardiac integration of skeletal muscle gr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2261-6-25

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Tolmachov, O More by this author
Coutelle, C More by this author
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Wellcome Trust More from this funder
British Heart Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Cardiovascular Disorders Journal website
Volume:
6
Pages:
Article: 25
Publication date:
2006
DOI:
ISSN:
1471-2261
URN:
uuid:d2e255df-739d-4046-829f-9cc006cdad9b
Source identifiers:
576095
Local pid:
pubs:576095

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