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O-h what a surprise

Abstract:

Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2. These lipoprotein complexes contain an active, pore-forming component, apolipoprotein L1 (ApoL1), that causes trypanosome cell death3. One of the two humaninfective subspecies, Trypanosoma brucei rhodesiense, differs from non-infective trypanosome...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41564-018-0211-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Physical and Theoretical Chemistry Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Physical and Theoretical Chemistry Laboratory
Role:
Author
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Name:
Medical Research Council
Grant:
MR/N020413/1
More from this funder
Name:
Wellcome Trust
Grant:
104923/Z/14/Z
Publisher:
Nature Publishing Group
Journal:
Nature Microbiology More from this journal
Volume:
3
Issue:
8
Pages:
856-857
Publication date:
2018-07-25
Acceptance date:
2018-07-25
DOI:
EISSN:
2058-5276
Pmid:
30046170
Language:
English
Keywords:
Pubs id:
pubs:905128
UUID:
uuid:d2aaee13-cf68-4f31-a14b-2a25ca758fe2
Local pid:
pubs:905128
Source identifiers:
905128
Deposit date:
2018-10-13

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