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A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.

Abstract:

DNA double-strand break (DSB) repair is a highly regulated process performed predominantly by non-homologous end joining (NHEJ) or homologous recombination (HR) pathways. How these pathways are coordinated in the context of chromatin is unclear. Here we uncover a role for histone H3K36 modification in regulating DSB repair pathway choice in fission yeast. We find Set2-dependent H3K36 methylation reduces chromatin accessibility, reduces resection and promotes NHEJ, while antagonistic Gcn5-depe...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms5091

Authors


Publisher:
Nature Publishing Group
Journal:
Nature communications More from this journal
Volume:
5
Pages:
4091
Publication date:
2014-01-01
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Language:
English
Pubs id:
pubs:469412
UUID:
uuid:d28de8b0-31dc-4927-b69f-f71711341fb5
Local pid:
pubs:469412
Source identifiers:
469412
Deposit date:
2015-02-25

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