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A multi-center study of neurofilament assay reliability and inter-laboratory variability

Abstract:

Objectives: Significantly elevated levels of neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH) have been described in the blood and cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients. The aim of this study was to evaluate the analytical performance of different neurofilament assays in a round robin with 10 centers across Europe/U.S.

Methods: Serum, plasma and CSF samples from a group of five ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Name:
Amyotrophic Lateral Sclerosis Association
Grant:
595-18
Publisher:
Taylor and Francis
Journal:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration More from this journal
Volume:
21
Issue:
5-6
Pages:
452-458
Publication date:
2020-06-19
Acceptance date:
2020-06-03
DOI:
EISSN:
2167-9223
ISSN:
2167-8421
Language:
English
Keywords:
Pubs id:
1108699
Local pid:
pubs:1108699
Deposit date:
2020-06-03

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