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Oscillatory pallidal local field potential activity inversely correlates with limb dyskinesias in Parkinson's disease.

Abstract:

Levodopa induced dyskinesias (LIDs) are poorly understood and yet are a major cause of disability in Parkinson's disease (PD). The activity of neurons in the basal ganglia of patients with PD tends to be strongly synchronized at frequencies under 30 Hz, leading to oscillatory local field potentials (LFPs). As dopaminergic therapy acutely suppresses this synchronization, we investigated whether this suppression may contribute to LIDs. Accordingly, we sought an inverse correlation between oscil...

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Publication status:
Published

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Authors


Silberstein, P More by this author
Oliviero, A More by this author
Di Lazzaro, V More by this author
Mazzone, P More by this author
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Journal:
Experimental neurology
Volume:
194
Issue:
2
Pages:
523-529
Publication date:
2005-08-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:d259c45c-3d04-43ef-92e6-bf3cefa672af
Source identifiers:
122450
Local pid:
pubs:122450

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