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Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites.

Abstract:

We calculated the number and growth rate of Plasmodium falciparum parasites emerging in recipients of candidate preerythrocytic malaria vaccines and unvaccinated control subjects undergoing mosquito-bite challenge. This was done to measure vaccine efficacy and to distinguish the effects on blood-stage multiplication from those on liver-stage parasites. Real-time polymerase chain reaction measurements of parasite densities were analyzed by nonlinear regression and mixed-effects models. Substan...

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Publication status:
Published

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Publisher copy:
10.1086/427243

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Andrews, L More by this author
Andersen, RF More by this author
Dunachie, S More by this author
Webster, D More by this author
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Journal:
The Journal of infectious diseases
Volume:
191
Issue:
4
Pages:
619-626
Publication date:
2005-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:d23cbea5-8860-4a05-85ba-895462d21c23
Source identifiers:
32957
Local pid:
pubs:32957

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