- Abstract:
-
We calculated the number and growth rate of Plasmodium falciparum parasites emerging in recipients of candidate preerythrocytic malaria vaccines and unvaccinated control subjects undergoing mosquito-bite challenge. This was done to measure vaccine efficacy and to distinguish the effects on blood-stage multiplication from those on liver-stage parasites. Real-time polymerase chain reaction measurements of parasite densities were analyzed by nonlinear regression and mixed-effects models. Substan...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1086/427243
-
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- Journal:
- The Journal of infectious diseases
- Volume:
- 191
- Issue:
- 4
- Pages:
- 619-626
- Publication date:
- 2005-02-05
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- URN:
-
uuid:d23cbea5-8860-4a05-85ba-895462d21c23
- Source identifiers:
-
32957
- Local pid:
- pubs:32957
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites.
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