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Interferon lambdas: the next cytokine storm.

Abstract:

For two decades the scientific community has sought to understand why some people clear hepatitis C virus (HCV) and others do not. Recently, several large genome-wide association studies have identified single nucleotide polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the spontaneous resolution and successful treatment of HCV infection. These observations are generating intense research activity; the hope is that IFNλ3 genetic variants may serve as importan...

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Publication status:
Published

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Publisher copy:
10.1136/gut.2010.222976

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
Journal:
Gut
Volume:
60
Issue:
9
Pages:
1284-1293
Publication date:
2011-09-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:d2073145-3b0c-452d-a127-f2cfac330514
Source identifiers:
118043
Local pid:
pubs:118043

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