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Vital rates from the action of mutation accumulation

Abstract:
New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed explanations of Gompertz hazards and mortality plateaus, and use them to explore the possibility of melding evolutionary and functional models of aging.

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Publisher copy:
10.1007/s12062-009-9015-3

Authors


Wachter, KW More by this author
Steinsaltz, DR More by this author
Journal:
Journal of Population Ageing
Volume:
2
Issue:
1-2
Pages:
5-22
Publication date:
2008-08-27
DOI:
EISSN:
1874-7876
ISSN:
1874-7884
URN:
uuid:d1f64c3a-33e9-4c88-9c92-e0a3f6b1a017
Source identifiers:
97839
Local pid:
pubs:97839
Language:
English
Keywords:

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