Journal article
The tetrameric plant lectin BanLec neutralizes HIV through bidentate binding to specific viral glycans.
- Abstract:
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Select lectins have powerful antiviral properties that effectively neutralize HIV-1 by targeting the dense glycan shield on the virus. Here, we reveal the mechanism by which one of the most potent lectins, BanLec, achieves its inhibition. We identify that BanLec recognises a subset of high-mannose glycans via bidentate interactions spanning the two binding sites present on each BanLec monomer that were previously considered separate carbohydrate recognition domains. We show that both sites ar...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 609.5KB)
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- Publisher copy:
- 10.1016/j.str.2017.03.015
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Authors
Funding
+ International AIDS Vaccine Initiative Neutralizing Antibody Center
More from this funder
Funding agency for:
Crispin, M
Grant:
1UM1AI100663
+ National Institute of Allergy and Infectious Diseases
More from this funder
Funding agency for:
Crispin, M
Grant:
1UM1AI100663
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Benesch, J
Grant:
BB/L017733/1
+ Medical Research Council
More from this funder
Funding agency for:
Robinson, C
Grant:
Professorship
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 25
- Issue:
- 5
- Pages:
- 773-782.e5
- Publication date:
- 2017-04-20
- Acceptance date:
- 2017-03-23
- DOI:
- ISSN:
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1878-4186 and 0969-2126
- Source identifiers:
-
691199
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:691199
- UUID:
-
uuid:d1c45d29-2a51-4672-a816-2042574deb37
- Local pid:
- pubs:691199
- Deposit date:
- 2017-05-11
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2017
- Notes:
- © 2017 Published by Elsevier Ltd.. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: http://dx.doi.org/10.1016/j.str.2017.03.015
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