Journal article icon

Journal article

The tetrameric plant lectin BanLec neutralizes HIV through bidentate binding to specific viral glycans.

Abstract:

Select lectins have powerful antiviral properties that effectively neutralize HIV-1 by targeting the dense glycan shield on the virus. Here, we reveal the mechanism by which one of the most potent lectins, BanLec, achieves its inhibition. We identify that BanLec recognises a subset of high-mannose glycans via bidentate interactions spanning the two binding sites present on each BanLec monomer that were previously considered separate carbohydrate recognition domains. We show that both sites ar...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1016/j.str.2017.03.015

Authors


More by this author
Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Role:
Author
More by this author
Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Benesch, JLP
More from this funder
Funding agency for:
Robinson, CV
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
Structure Journal website
Volume:
25
Issue:
5
Pages:
773-782.e5
Publication date:
2017-04-20
Acceptance date:
2017-03-23
DOI:
ISSN:
1878-4186 and 0969-2126
Pubs id:
pubs:691199
URN:
uri:d1c45d29-2a51-4672-a816-2042574deb37
UUID:
uuid:d1c45d29-2a51-4672-a816-2042574deb37
Local pid:
pubs:691199
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP