Journal article

DNA nanotweezers studied with a coarse-grained model of DNA

Abstract:: We introduce a coarse-grained rigid nucleotide model of DNA that reproduces the basic thermodynamics of short strands: duplex hybridization, single-stranded stacking and hairpin formation, and also captures the essential structural properties of DNA: the helical pitch, persistence length and torsional stiffness of double-stranded molecules, as well as the comparative flexibility of unstacked single strands. We apply the model to calculate the detailed free-energy landscape of one full cycle of DNA 'tweezers', a simple machine driven by hybridization and strand displacement.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Ouldridge, T., Louis, A., & Doye, J. (2010). DNA nanotweezers studied with a coarse-grained model of DNA. Physical Review Letters, 104(17).

MLA Style

Ouldridge, T., et al. “DNA Nanotweezers Studied with a Coarse-Grained Model of DNA.” Physical Review Letters, vol. 104, no. 17, American Physical Society, 2010.

Chicago Style

Ouldridge, T, A Louis, and J Doye. 2010. “DNA Nanotweezers Studied with a Coarse-Grained Model of DNA.” Physical Review Letters 104 (17).
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Files:: 0911.0555v1.pdf

(Preview, Author's original, pdf, 1.3MB, Terms of use)

Publisher copy:: 10.1103/PhysRevLett.104.178101

Authors

+ Ouldridge, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Physics
Sub department:: Theoretical Physics
Role:: Author

+ Louis, A More by this author

Institution:: University of Oxford
Role:: Author

+ Doye, J More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Physical & Theoretical Chem
Role:: Author

Publisher:: American Physical Society
Journal:: Physical Review Letters More from this journal
Volume:: 104
Issue:: 17
Article number:: 178101
Publication date:: 2010-01-01
DOI:: 10.1103/PhysRevLett.104.178101
EISSN:: 1079-7114
ISSN:: 0031-9007

Language:: English
Keywords:: cond-mat.soft

q-bio.BM

physics.bio-ph
Pubs id:: pubs:45789
UUID:: uuid:d1c23ce8-0c44-41e7-8aa4-66047e599cad
Local pid:: pubs:45789
Source identifiers:: 45789
Deposit date:: 2013-03-20

Terms of use

Copyright holder:: American Physical Society
Copyright date:: 2010
Notes:: Copyright 2010 The American Physical Society.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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