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Journal article

The INT6 cancer gene and MEK signaling pathways converge during zebrafish development.

Abstract:

BACKGROUND: Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking. PRINCIPAL FINDINGS: Here, we create an in vivo model of Int6 function in zebrafish, and through genetic and chemical-genetic approaches implicate Int6 as a tissue...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0000959

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Institution:
University of Oxford
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Institution:
University of Oxford
Anastasaki, C More by this author
Amatruda, JF More by this author
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Funding agency for:
Norbury, CJ
Medical Research Council More from this funder
Cancer Research UK More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
2
Issue:
9
Pages:
e959
Publication date:
2007
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:d1bf24fc-8258-4e28-91d1-d2eb5571c72e
Source identifiers:
15803
Local pid:
pubs:15803

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