Journal article

Applications of acoustics and cavitation to noninvasive therapy and drug delivery

Abstract:: Biomedical acoustics is rapidly evolving from a diagnostic modality into a therapeutic tool, and acoustic cavitation is often the common denominator in a wide range of new therapeutic applications. High-intensity focused ultrasound (HIFU) waves generated outside the body can be used to deposit heat deep within the body. Through a quantitative analysis of heat deposition by ultrasound, it is shown that inertial cavitation can help address some of the major challenges of HIFU therapy by providing a means of enhancing and monitoring treatment noninvasively. In the context of drug delivery, both inertial and stable cavitation play roles in enhancing drug activity and uptake. In particular, shape oscillations arising during stable cavitation provide an effective micropumping mechanism for enhanced mass transport across inaccessible interfaces.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Coussios, C., & Roy, R. (2008). Applications of acoustics and cavitation to noninvasive therapy and drug delivery. Annual Review of Fluid Mechanics, 40, 395–420.

MLA Style

Coussios, C, and R Roy. “Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery.” Annual Review of Fluid Mechanics, vol. 40, 2008, pp. 395–420.

Chicago Style

Coussios, C, and R Roy. 2008. “Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery.” Annual Review of Fluid Mechanics 40: 395–420.
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Files:: ARFMFullPaperFinal2.pdf

(Preview, Author's original, pdf, 587.9KB, Terms of use)

Publisher copy:: 10.1146/annurev.fluid.40.111406.102116

Authors

+ Coussios, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Engineering Science
Oxford college:: Magdalen College
Role:: Author

+ Roy, R More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Engineering Science
Oxford college:: Harris Manchester College
Role:: Author

Publisher:: Annual Reviews
Journal:: Annual Review of Fluid Mechanics More from this journal
Volume:: 40
Pages:: 395-420
Publication date:: 2008-01-31
DOI:: 10.1146/annurev.fluid.40.111406.102116
ISSN:: 0066-4189

Keywords:: SBTMR
Pubs id:: pubs:160695
UUID:: uuid:d1baf396-d51c-4a49-bd81-2a152819208d
Local pid:: pubs:160695
Source identifiers:: 160695
Deposit date:: 2018-11-26
ARK identifier:: ark:/29072/ora_d1baf396d51c4a49bd812a152819208d

Terms of use

Copyright holder:: Annual Reviews
Copyright date:: 2008
Notes:: © Annual Reviews 2008. This is the author's original version of the article. The final version is available online from Annual Reviews at: https://doi.org/10.1146/annurev.fluid.40.111406.102116

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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