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Lambert-Eaton syndrome IgG inhibits transmitter release via P/Q Ca2+ channels.

Abstract:

OBJECTIVE: To determine whether immunoglobulin G (IgG) from patients with Lambert-Eaton myasthenic syndrome (LEMS) decreases action potential-evoked synaptic vesicle exocytosis, and whether the effect is mediated by P/Q-type voltage-gated calcium channels (VGCCs). METHODS: IgG was obtained from 4 patients with LEMS (3 males, 1 female), including 2 patients with lung malignancy. Antibodies against P/Q-type VGCCs were detected in all 4 patients, and against N-type VGCCs in 2. We incubated neuro...

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Authors


Spillane, J More by this author
Ermolyuk, Y More by this author
Cano-Jaimez, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Publisher:
Lippincott Williams and Wilkins
Journal:
Neurology
Volume:
84
Issue:
6
Pages:
575-579
Publication date:
2015-01-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:d18b27a3-8f91-418b-844f-f2eb43462937
Source identifiers:
504928
Local pid:
pubs:504928
Language:
English

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