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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Abstract:

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signal...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2897

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Journal:
Nature genetics
Volume:
46
Issue:
3
Pages:
234-244
Publication date:
2014-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d18575af-6213-4c22-9263-11fd44c33bab
Source identifiers:
458375
Local pid:
pubs:458375

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