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MAIT cells and viruses

Abstract:

Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. Functionally they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this is true when considering recognition through the TCR. However, MAIT cells are dist...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/imcb.12008

Authors


Ussher, JE More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Oxford college:
Green Templeton College
Oxford Dominions Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
96
Issue:
6
Pages:
630-641
Publication date:
2018-01-19
Acceptance date:
2018-01-09
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Pubs id:
pubs:821377
URN:
uri:d14b2f5e-5e5b-42d0-9e94-30f128cc8789
UUID:
uuid:d14b2f5e-5e5b-42d0-9e94-30f128cc8789
Local pid:
pubs:821377
Language:
English
Keywords:

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