Journal article icon

Journal article

High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.

Abstract:

All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in N-glycosylation of IgG associate with various diseases and affect the activity of therapeutic antibodies and intravenous immunoglobulins. We have developed a novel 96-well protein G monolithic plate and used it to rapidly isolate IgG from plasma of 2298 individuals from three isolated human populations. N-glycans were released by PNGase F, labeled with 2-aminobenzamide and analyzed by hydrophi...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/mcp.m111.010090

Authors


Expand authors...
Journal:
Molecular and cellular proteomics : MCP
Volume:
10
Issue:
10
Pages:
M111.010090
Publication date:
2011-10-05
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
URN:
uuid:d11f6fd2-4cb0-46d8-a462-c8fa7bc43eb5
Source identifiers:
151219
Local pid:
pubs:151219

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP