Thesis icon

Thesis

Investigation of genetic determinants of drug response in a Plasmodium falciparum genetic cross using a high-throughput screening method

Abstract:

The emergence and rapid spread of artemisinin-resistant Plasmodium falciparum in southeast Asia highlights the importance of identifying genetic determinants of drug response and discovering novel potent antimalarials. In support of these efforts, the parental lines and progeny of the 803xGB4 genetic cross were characterized by pharmaceutical compound screening and whole-genome sequencing (WGS). Results of the compound screen identified 52 highly-active compounds with potential fo...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
U.S. National Institutes of Health
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:d11eb018-c23a-4c67-97de-f724a39d5df4
Deposit date:
2016-05-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP