Thesis
Functional characterisation of key residues in the photopigment melanopsin
- Abstract:
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Melanopsin (Opn4) is the opsin photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs). It has a conserved opsin structure and activation mechanism, yet demonstrates unusual functional properties that suggest it will possess unique structure-function relationships. The aim of this thesis was to characterise key OPN4 residues by examining the impact of non-synonymous mutations on melanopsin function. A genotype-driven screen of a chemically-mutagenized...
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Authors
Contributors
+ Hankins, M
Department:
University of Oxford
Role:
Supervisor
+ Peirson, S
Department:
University of Oxford
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:d1184150-9b61-4cc9-94ad-2cc13a3d21ce
- Deposit date:
- 2017-04-20
Terms of use
- Copyright holder:
- Rodgers, J; Jessica Rodgers.
- Copyright date:
- 2016
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