Journal article

Population and functional genomics of Neisseria revealed with gene-by-gene approaches

Abstract:: Rapid low-cost whole-genome sequencing (WGS) is revolutionizing microbiology; however, complementary advances in accessible, reproducible, and rapid analysis techniques are required to realize the potential of these data. Here, investigations of the genus Neisseria illustrated the gene-by-gene conceptual approach to the organization and analysis of WGS data. Using the gene and its link to phenotype as a starting point, the BIGSdb database, which powers the PubMLST databases, enables the assembly of large open-access collections of annotated genomes that provide insight into the evolution of the Neisseria, the epidemiology of meningococcal and gonococcal disease, and mechanisms of Neisseria pathogenicity.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Maiden, M. C. J., & Harrison, O. B. (2016). Population and functional genomics of Neisseria revealed with gene-by-gene approaches. Journal of Clinical Microbiology, 54(8), 1949–1955.

MLA Style

Maiden, M. CJ, and O. B. Harrison. “Population and Functional Genomics of Neisseria Revealed with Gene-by-Gene Approaches.” Journal of Clinical Microbiology, vol. 54, no. 8, American Society of Microbiology, 2016, pp. 1949–55.

Chicago Style

Maiden, MCJ, and OB Harrison. 2016. “Population and Functional Genomics of Neisseria Revealed with Gene-by-Gene Approaches.” Journal of Clinical Microbiology 54 (8): 1949–55.
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Files:: Maiden_and_Harrison_2016_Population_and_functional.pdf

(Preview, Version of record, pdf, 697.3KB, Terms of use)

Publisher copy:: 10.1128/JCM.00301-16

Authors

+ Maiden, MCJ More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Zoology
Role:: Author

+ Harrison, OB More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Zoology
Role:: Author

+ Wellcome Trust More from this funder

Funder identifier:: https://ror.org/029chgv08
Grant:: 104992; 087622

Publisher:: American Society of Microbiology
Journal:: Journal of Clinical Microbiology More from this journal
Volume:: 54
Issue:: 8
Pages:: 1949-1955
Publication date:: 2016-07-25
Acceptance date:: 2016-04-13
DOI:: 10.1128/JCM.00301-16
EISSN:: 1098-660X
ISSN:: 0095-1137
Pmid:: 27098959

Language:: English
Pubs id:: pubs:619035
UUID:: uuid:d116b071-5a2c-4154-ada7-f6a93b17b6ea
Local pid:: pubs:619035
Source identifiers:: 619035
Deposit date:: 2016-09-27

Terms of use

Copyright holder:: Maiden and Harrison
Copyright date:: 2016
Rights statement:: Copyright © 2016 Maiden and Harrison. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Licence:: CC Attribution (CC BY)

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