Journal article
Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug.
- Abstract:
-
BACKGROUND: Prostate cancer cells secrete unique proteases such as prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) that represent targets for the activation of prodrugs as systemic treatment of metastatic prostate cancer. Previously, a combinatorial peptide library was screened to identify a highly active peptide substrate for hK2. The peptide was coupled to an analog of the potent cytotoxin thapsigargin, L12ADT, to generate an hK2-activated prodrug that was efficientl...
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- Publisher copy:
- 10.1002/pros.20348
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Authors
Bibliographic Details
- Journal:
- Prostate
- Volume:
- 66
- Issue:
- 4
- Pages:
- 358-368
- Publication date:
- 2006-03-01
- DOI:
- EISSN:
-
1097-0045
- ISSN:
-
0270-4137
- Source identifiers:
-
365968
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:365968
- UUID:
-
uuid:d1070e11-b4d4-46b5-90c9-96942ad2eecf
- Local pid:
- pubs:365968
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2006
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