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Journal article

Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug.

Abstract:

BACKGROUND: Prostate cancer cells secrete unique proteases such as prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) that represent targets for the activation of prodrugs as systemic treatment of metastatic prostate cancer. Previously, a combinatorial peptide library was screened to identify a highly active peptide substrate for hK2. The peptide was coupled to an analog of the potent cytotoxin thapsigargin, L12ADT, to generate an hK2-activated prodrug that was efficientl...

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Publisher copy:
10.1002/pros.20348

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Journal:
Prostate
Volume:
66
Issue:
4
Pages:
358-368
Publication date:
2006-03-01
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
Source identifiers:
365968
Language:
English
Keywords:
Pubs id:
pubs:365968
UUID:
uuid:d1070e11-b4d4-46b5-90c9-96942ad2eecf
Local pid:
pubs:365968
Deposit date:
2013-11-16

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