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Potent neutralizing human monoclonal antibodies preferentially target mature dengue virus particles: implication for novel strategy of dengue vaccine

Abstract:

The four serotypes of dengue virus (DENV) cause the most important mosquito-borne viral disease in humans. The envelope (E) protein is the major target of neutralizing antibodies and contains 3 domains (DI, DII and DIII). Recent studies reported that human monoclonal antibodies (mAbs) recognizing the DIII, D1/DII hinge, the E-dimer epitope or a quaternary epitope involving DI/DII/DIII are more potently neutralizing compared with those recognizing the fusion-loop (FL) of DII. Due to inefficien...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1128/jvi.00556-18

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Screaton, G
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Funding agency for:
Screaton, G
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
92
Issue:
23
Pages:
Article: e00556-18
Publication date:
2018-09-05
Acceptance date:
2018-08-22
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:916962
URN:
uri:d0b4c0ba-4451-4ba5-911b-5c253ae043eb
UUID:
uuid:d0b4c0ba-4451-4ba5-911b-5c253ae043eb
Local pid:
pubs:916962
Language:
English
Keywords:

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