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Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates

Abstract:
Background The β-lactam antibiotics represent the most successful drug class for treatment of bacterial infections. Resistance to them, importantly via production of β-lactamases, which collectively are able to hydrolyse all classes of β-lactams, threatens their continued widespread use. Bicyclic boronates show potential as broad spectrum inhibitors of the mechanistically distinct serine- (SBL) and metallo- (MBL) β-lactamase families.

Methods Using... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbagen.2019.02.004

Authors


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Institution:
University of Oxford
Department:
Chemistry
Role:
Author
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Name:
Wellcome Trust
Grant:
106244/Z/14/Z
More from this funder
Name:
Medical Research Council
Grant:
RLFGD3027 (MR/N002679/1
Publisher:
Elsevier
Journal:
Biochimica et Biophysica Acta (BBA) - General Subjects More from this journal
Volume:
1863
Issue:
4
Pages:
742-748
Publication date:
2019-02-07
Acceptance date:
2019-02-04
DOI:
ISSN:
0304-4165
Pubs id:
pubs:969073
UUID:
uuid:d0b248be-babf-4e08-b26a-51e049334873
Local pid:
pubs:969073
Source identifiers:
969073
Deposit date:
2019-02-06

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