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The HIV-1 5' LTR poly(A) site is inactivated by U1 snRNP interaction with the downstream major splice donor site.

Abstract:

The inactivity of the 5' long terminal repeat (LTR) poly(A) site immediately downstream of the cap site maximizes the production of HIV-1 transcripts. In this paper, we demonstrate that this inactivity is mediated by the interaction of the U1 snRNP with the major splice donor site (MSD). The inhibition of the HIV-1 poly(A) site by U1 snRNP relies on a series of delicately balanced RNA processing signals. These include the poly(A) site, the major splice donor site and the splice acceptor sites...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/16.18.5752

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
EMBO journal More from this journal
Volume:
16
Issue:
18
Pages:
5752-5763
Publication date:
1997-09-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:8366
UUID:
uuid:d0ad33df-9e3c-4416-8004-ff59532c52e4
Local pid:
pubs:8366
Source identifiers:
8366
Deposit date:
2012-12-19

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