Journal article icon

Journal article

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

Abstract:

Background: Thymopoiesis requires thymocyte-stroma interactions and proteases that promote cell migration by degrading extracellular matrix and releasing essential cytokines and chemokines. A role for several members of the A Disintegrin and Metalloprotease (ADAM) family in T cell development has been reported in the past. Methodology/Principal Findings: Here, we present data indicating that the family member ADAM8 plays a role in thymic T cell development. We used qrtPCR on FACS sorted thymi...

Expand abstract

Actions


Access Document


Authors


Journal:
PLoS ONE
Volume:
5
Issue:
9
Pages:
1-9
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
Source identifiers:
309058
Language:
English
Pubs id:
pubs:309058
UUID:
uuid:d0a42a41-766e-448c-af84-26422c0e33f2
Local pid:
pubs:309058
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP