Journal article
Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity
- Abstract:
-
Background: Thymopoiesis requires thymocyte-stroma interactions and proteases that promote cell migration by degrading extracellular matrix and releasing essential cytokines and chemokines. A role for several members of the A Disintegrin and Metalloprotease (ADAM) family in T cell development has been reported in the past. Methodology/Principal Findings: Here, we present data indicating that the family member ADAM8 plays a role in thymic T cell development. We used qrtPCR on FACS sorted thymi...
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Bibliographic Details
- Journal:
- PLoS ONE
- Volume:
- 5
- Issue:
- 9
- Pages:
- 1-9
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
-
1932-6203
Item Description
- Language:
- English
- Pubs id:
-
pubs:309058
- UUID:
-
uuid:d0a42a41-766e-448c-af84-26422c0e33f2
- Local pid:
- pubs:309058
- Source identifiers:
-
309058
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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