- Abstract:
-
Programmed cell death ligand 1 (PD-L1) interacts with programmed cell death protein-1 (PD-1) as an immune checkpoint. Reactivating the immune response by inhibiting PD-L1 using therapeutic antibodies provides substantial clinical benefits in many, though not all, melanoma patients. However, transcriptional suppression of PD-L1 expression as an alternative therapeutic anti-melanoma strategy has not been exploited. Here we provide biochemical evidence demonstrating that ultraviolet radiation (U...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 103.8kb)
-
(pdf, 104.7kb)
-
(pdf, 147.6kb)
-
(pdf, 115.0kb)
-
(pdf, 57.1kb)
-
(tiff, 752.5kb)
-
(pdf, 227.5kb)
-
(pdf, 209.9kb)
-
- Publisher copy:
- 10.1038/s41388-018-0314-0
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Grant:
- R01CA137098, R01CA193913 and R01CA196896
- Grant:
- Integration of Chinese and Western Medicine grant (PC)
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Oncogene Journal website
- Volume:
- 37
- Pages:
- 4941–4954
- Publication date:
- 2018-05-22
- Acceptance date:
- 2018-04-20
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- Pubs id:
-
pubs:846503
- URN:
-
uri:d0985f16-1fd8-4bd3-8a63-26e8b0d45bee
- UUID:
-
uuid:d0985f16-1fd8-4bd3-8a63-26e8b0d45bee
- Local pid:
- pubs:846503
- Keywords:
- Copyright holder:
- Zhu et al.
- Copyright date:
- 2018
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41388-018-0314-0
Journal article
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ National Institutes of Health
More from this funder
+ Priority Academic Program Development of Jiangsu Higher Education Institutions
More from this funder
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record