Journal article
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy
- Abstract:
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Programmed cell death ligand 1 (PD-L1) interacts with programmed cell death protein-1 (PD-1) as an immune checkpoint. Reactivating the immune response by inhibiting PD-L1 using therapeutic antibodies provides substantial clinical benefits in many, though not all, melanoma patients. However, transcriptional suppression of PD-L1 expression as an alternative therapeutic anti-melanoma strategy has not been exploited. Here we provide biochemical evidence demonstrating that ultraviolet radiation (U...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
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- Publisher copy:
- 10.1038/s41388-018-0314-0
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Authors
Funding
+ National Institutes of Health
More from this funder
Grant:
R01CA137098, R01CA193913 and R01CA196896
+ Priority Academic Program Development of Jiangsu Higher Education Institutions
More from this funder
Grant:
Integration of Chinese and Western Medicine grant (PC)
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Oncogene Journal website
- Volume:
- 37
- Pages:
- 4941–4954
- Publication date:
- 2018-05-22
- Acceptance date:
- 2018-04-20
- DOI:
- EISSN:
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1476-5594
- ISSN:
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0950-9232
- Pubs id:
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pubs:846503
- URN:
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uri:d0985f16-1fd8-4bd3-8a63-26e8b0d45bee
- UUID:
-
uuid:d0985f16-1fd8-4bd3-8a63-26e8b0d45bee
- Local pid:
- pubs:846503
Item Description
- Keywords:
Terms of use
- Copyright holder:
- Zhu et al.
- Copyright date:
- 2018
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41388-018-0314-0
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