Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.

Journal article

Fetal cells enter the maternal circulation from the early first trimester of pregnancy, where they persist in tissue decades later. We investigated in mice whether fetal microchimeric cells (FMCs) can be detected in maternal kidney, and whether they play a role in kidney homeostasis. FMCs were identified in vivo in two models: one an adaptive model following unilateral nephrectomy, the other an injury via unilateral renal ischaemia reperfusion. Both models were carried out in mothers that had...

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Authors: Bou-Gharios, G; Amin, F; Hill, P; Nakamura, H; Maxwell, P

• Publication status: Published
• Journal: Cells, tissues, organs
• Volume: 193
• Issue: 6
• Pages: 379-392
• Publication date: 2011-01-01
• DOI: 10.1159/000321172
• EISSN: 1422-6421
• ISSN: 1422-6405
• Language: English
• Keywords: Wound Healing; In Situ Hybridization, Fluorescence; Chimerism; Fetus; Female; Reverse Transcriptase Polymerase Chain Reaction; Cell Movement; Bone Marrow Cells; Mice, Inbred C57BL; Y Chromosome; Luminescent Measurements; Mice; beta-Galactosidase; Kidney; Transgenes; Animals; Transcription, Genetic; Collagen Type I; Cell Count; Luciferases