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An integrated taxonomy for monogenic inflammatory bowel disease

Abstract:

Background and aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the essential roles of individual genes in pathways and networks safeguarding immune tolerance and gut homeostasis. Methods To build a taxonomy model we assessed 165 disorders. Genes were prioritized based on penetrance of IBD and disease phenotypes were integrated with multi-omics datasets. Monogenic IBD genes were classified by: (1) overlapping syndromic features; (2) response to hematopoietic stem cell trans...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier Publisher's website
Journal:
Gastroenterology Journal website
Publication date:
2021-11-12
Acceptance date:
2021-11-08
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Language:
English
Keywords:
Pubs id:
1210529
Local pid:
pubs:1210529
Deposit date:
2021-11-19

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