- Abstract:
-
DNA polymerase III, a decameric 420-kDa assembly, simultaneously replicates both strands of the chromosome in Escherichia coli. A subassembly of this holoenzyme, the seven-subunit clamp loader complex, is responsible for loading the sliding clamp (β2) onto DNA. Here, we use structural information derived from ion mobility mass spectrometry (IM-MS) to build three-dimensional models of one form of the full clamp loader complex, γ3δδ′ψχ (254 kDa). By probing the interaction between the clamp loa...
Expand abstract - Publisher copy:
- 10.1016/j.jmb.2013.04.006
-
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- Journal:
- Journal of Molecular Biology
- Volume:
- 425
- Issue:
- 23
- Pages:
- 4790-4801
- Publication date:
- 2013-11-29
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:d0920f15-52fe-4a27-a76e-7906e2c18546
- Source identifiers:
-
440680
- Local pid:
- pubs:440680
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Integrative modelling coupled with ion mobility mass spectrometry reveals structural features of the clamp loader in complex with single-stranded DNA binding protein
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