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Population pharmacokinetics of intramuscular artesunate in african children with severe malaria: Implications for a practical dosing regimen

Abstract:

Parenteral artesunate (ARS) is the drug of choice for the treatment of severe malaria. Pharmacokinetics data on intramuscular ARS are limited with respect to the main treatment group that carries the highest mortality, namely, critically ill children with severe malaria. A population pharmacokinetic study of ARS and dihydroartemisinin (DHA) was conducted from sparse sampling in 70 Tanzanian children of ages 6 months to 11 years. All the children had been admitted with severe falciparum malari...

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Publisher copy:
10.1038/clpt.2013.26

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Journal:
Clinical Pharmacology and Therapeutics
Volume:
93
Issue:
5
Pages:
443-450
Publication date:
2013-05-05
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
URN:
uuid:d09119cd-ac6a-4f53-a7ff-cf9646274085
Source identifiers:
405633
Local pid:
pubs:405633
Language:
English

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