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Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeat.

Abstract:

We examined the stability and kinetics of folding of the Oxytricha telomeric repeat sequence (G4T4)4. Fluorescence melting experiments show that this intramolecular quadruplex, which is more stable in potassium- than sodium-containing buffers, shows considerable hysteresis between the melting and annealing profiles, even when heated at a rate of 0.05 degrees C min(-1). Quantitative analysis of this hysteresis, together with temperature-jump relaxation experiments show that the dissociation is...

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Publication status:
Published

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Publisher copy:
10.1039/b511706b

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic and biomolecular chemistry
Volume:
3
Issue:
22
Pages:
4153-4157
Publication date:
2005-11-01
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Language:
English
Keywords:
Pubs id:
pubs:400039
UUID:
uuid:d08c88b7-54c5-414b-9c7f-821a2385fc03
Local pid:
pubs:400039
Source identifiers:
400039
Deposit date:
2013-11-16

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