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Journal article

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

Abstract:

Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes. A key finding of our study is the identification of mutations in insulin-like growth factor (IGF) signalling genes in 8/112 (7%) of cases. We validate this observation using fluorescence in situ hybridization (FISH) in an additional 87 osteosarcomas, with IG...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms15936

Authors


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Royal National Orthopaedic Hospital NHS Trust More from this funder
Skeletal Cancer Action Trust More from this funder
Rosetrees Trust UK More from this funder
Bone Cancer Research Trust More from this funder
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Publisher:
Nature Communications Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
15936
Publication date:
2017-06-01
Acceptance date:
2017-05-15
DOI:
ISSN:
2041-1723
Pmid:
28643781
Source identifiers:
702365
Language:
English
Keywords:
Pubs id:
pubs:702365
UUID:
uuid:d079a773-c50e-4d9e-aeb3-cbbc13675508
Local pid:
pubs:702365
Deposit date:
2017-08-25

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