- Abstract:
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Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes. A key finding of our study is the identification of mutations in insulin-like growth factor (IGF) signalling genes in 8/112 (7%) of cases. We validate this observation using fluorescence in situ hybridization (FISH) in an additional 87 osteosarcomas, with IG...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
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(pdf, 2.0MB)
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- Publisher copy:
- 10.1038/ncomms15936
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- Publisher:
- Nature Communications Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Pages:
- 15936
- Publication date:
- 2017-06-13
- Acceptance date:
- 2017-05-15
- DOI:
- ISSN:
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2041-1723
- Pubs id:
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pubs:702365
- URN:
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uri:d079a773-c50e-4d9e-aeb3-cbbc13675508
- UUID:
-
uuid:d079a773-c50e-4d9e-aeb3-cbbc13675508
- Local pid:
- pubs:702365
- Language:
- English
- Keywords:
- Copyright holder:
- Wedge et al
- Copyright date:
- 2017
- Notes:
-
© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.
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Funding
Skeletal Cancer Action Trust
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Royal National Orthopaedic Hospital NHS Trust
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Rosetrees Trust UK
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Bone Cancer Research Trust
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