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Journal article

A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis

Abstract:

Obeticholic acid (OCA), a potent farnesoid X receptor agonist, was studied as monotherapy in an international, randomized, double‐blind, placebo‐controlled phase 2 study in patients with primary biliary cholangitis who were then followed for up to 6 years. The goals of the study were to assess the benefit of OCA in the absence of ursodeoxycholic acid, which is relevant for patients who are intolerant of ursodeoxycholic acid and at higher risk of disease progression. Patients were randomized a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/hep.29569

Authors


Kowdley, KV More by this author
Luketic, V More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Hirschfield, GM More by this author
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Publisher:
Wiley Publisher's website
Journal:
Hepatology Journal website
Volume:
67
Issue:
5
Pages:
1890-1902
Publication date:
2018-01-29
Acceptance date:
2017-09-27
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
Pubs id:
pubs:737220
URN:
uri:d0622472-10ca-4006-b30c-998e22acc8d7
UUID:
uuid:d0622472-10ca-4006-b30c-998e22acc8d7
Local pid:
pubs:737220
Language:
English
Keywords:

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