Journal article icon

Journal article

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

Abstract:

α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP. β-Amyloid levels and APP amyloidogenic processing were investigated in neuronal cell lines stably overexpressing wildtype and mutant α-synuclein. γ-Secretase activity and β-secretase expression were also measured. We show that α-synuclein expression induces β-amyloid secretion and amyloidogenic processi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0171925

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-0330-9604
More by this author
Role:
Author
ORCID:
0000-0001-5485-8748
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
2
Pages:
Article: 0171925
DOI:
EISSN:
1932-6203
Pubs id:
pubs:896193
URN:
uri:d044e4b8-a21f-421b-b133-8be411990ab7
UUID:
uuid:d044e4b8-a21f-421b-b133-8be411990ab7
Local pid:
pubs:896193
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP