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α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

Abstract:

α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP. β-Amyloid levels and APP amyloidogenic processing were investigated in neuronal cell lines stably overexpressing wildtype and mutant α-synuclein. γ-Secretase activity and β-secretase expression were also measured. We show that α-synuclein expression induces β-amyloid secretion and amyloidogenic processi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0171925

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-0330-9604
More by this author
Role:
Author
ORCID:
0000-0001-5485-8748
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
2
Article number:
0171925
Publication date:
2017-02-10
Acceptance date:
2017-01-29
DOI:
EISSN:
1932-6203
Pmid:
28187176
Source identifiers:
896193
Language:
English
Pubs id:
pubs:896193
UUID:
uuid:d044e4b8-a21f-421b-b133-8be411990ab7
Local pid:
pubs:896193
Deposit date:
2018-12-10

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