- Abstract:
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α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP. β-Amyloid levels and APP amyloidogenic processing were investigated in neuronal cell lines stably overexpressing wildtype and mutant α-synuclein. γ-Secretase activity and β-secretase expression were also measured. We show that α-synuclein expression induces β-amyloid secretion and amyloidogenic processi...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 2.0MB)
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- Publisher copy:
- 10.1371/journal.pone.0171925
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 12
- Issue:
- 2
- Pages:
- Article: 0171925
- DOI:
- EISSN:
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1932-6203
- Pubs id:
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pubs:896193
- URN:
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uri:d044e4b8-a21f-421b-b133-8be411990ab7
- UUID:
-
uuid:d044e4b8-a21f-421b-b133-8be411990ab7
- Local pid:
- pubs:896193
- Language:
- English
- Copyright holder:
- Roberts et al.
- Notes:
- Copyright © 2017 Roberts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
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