Journal article

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis

Abstract:: 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of β-lactam ring containing natural products. IPNS catalyses formation of the bicyclic penicillin nucleus from a tripeptide. 2OG oxygenases catalyse reactions that diversify the chemistry of β-lactams formed by both IPNS and non-oxidative enzymes. Reactions catalysed by the 2OG oxygenases of β-lactam biosynthesis not only involve their typical hydroxylation reactions, but also desaturation, epimerisation, rearrangement, and ring-forming reactions. Some of the enzymes involved in β-lactam biosynthesis exhibit remarkable substrate and product selectivities. We review the roles of 2OG oxygenases and IPNS in β-lactam biosynthesis, highlighting opportunities for application of knowledge of their roles, structures, and mechanisms.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Rabe, P., Kamps, J., Schofield, C., & Lohans, C. (2018). Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis. Natural Product Reports.

MLA Style

Rabe, P, et al. “Roles of 2-Oxoglutarate Oxygenases and Isopenicillin N Synthase in ß-Lactam Biosynthesis.” Natural Product Reports, 2018.

Chicago Style

Rabe, P, J Kamps, C Schofield, and C Lohans. 2018. “Roles of 2-Oxoglutarate Oxygenases and Isopenicillin N Synthase in ß-Lactam Biosynthesis.” Natural Product Reports.
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Files:: Rabe_2018_roles_of_2.pdf

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Publisher copy:: 10.1039/C8NP00002F

Authors

+ Rabe, P More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry; Organic Chemistry
Role:: Author

+ Kamps, J More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry; Organic Chemistry
Role:: Author

+ Schofield, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author
ORCID:: 0000-0002-0290-6565

+ Lohans, C More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry; Organic Chemistry
Role:: Author

+ Wellcome Trust More from this funder

Grant:: 106244/Z/14/Z

+ Medical Research Council More from this funder

Grant:: MR/N021053/1

+ Biotechnology and Biological Sciences Research Council More from this funder

Grant:: BB/L009846/1

+ Deutsche Akademie fur Naturforscher Leopoldina, Germany More from this funder

Funding agency for:: Rabe, P

+ Innovative Medicines Initiative More from this funder

More funders...

Publisher:: Royal Society of Chemistry
Journal:: Natural Product Reports More from this journal
Publication date:: 2018-03-29
Acceptance date:: 2018-03-06
DOI:: 10.1039/C8NP00002F
EISSN:: 0265-0568
ISSN:: 1460-4752

Pubs id:: pubs:844947
UUID:: uuid:d040fe2c-4bb2-49c9-bdac-6a369dc1028e
Local pid:: pubs:844947
Source identifiers:: 844947
Deposit date:: 2018-06-01
ARK identifier:: ark:/29072/ora_d040fe2c4bb249c9bdac6a369dc1028e

Terms of use

Copyright holder:: © Rabe, et al 2018
Copyright date:: 2018
Notes:: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence

Licence:: CC Attribution (CC BY)

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