Journal article
Reproducibility of molecular phenotypes after long-term differentiation to human iPSC-derived neurons: A multi-site omics study
- Abstract:
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Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of the same two iPSC lines across five distinct laboratories. Despite uncovering acceptable variability within individual laboratories, we detect poor cross-site reproducibility of the differential gene expression signature between these two lines. Factor analy...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.2MB)
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- Publisher copy:
- 10.1016/j.stemcr.2018.08.013
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Authors
Funding
+ National Institute for Health Research
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Funding agency for:
Handel, A
Grant:
Biomedical Research Centre, Oxford
+ National Institute for Health Research
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Funding agency for:
Cader, M
Grant:
Biomedical Research Centre, Oxford
+ National Institute for Health Research
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Funding agency for:
Chintawar, S
Grant:
Biomedical Research Centre, Oxford
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Stem Cell Reports Journal website
- Volume:
- 11
- Issue:
- 4
- Pages:
- 897-911
- Publication date:
- 2018-09-20
- Acceptance date:
- 2018-08-21
- DOI:
- EISSN:
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2213-6711
- Pmid:
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30245212
- Source identifiers:
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921757
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:921757
- UUID:
-
uuid:d040c80d-73f8-4612-a8b2-2a2a29660fe9
- Local pid:
- pubs:921757
- Deposit date:
- 2018-09-28
Terms of use
- Copyright holder:
- Volpato et al
- Copyright date:
- 2018
- Notes:
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© 2018 The Authors. This is an open access article under the CC BY-NC-ND
license
- Licence:
- CC Attribution (CC BY)
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