Journal article icon

Journal article

Reproducibility of molecular phenotypes after long-term differentiation to human iPSC-derived neurons: A multi-site omics study

Abstract:

Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of the same two iPSC lines across five distinct laboratories. Despite uncovering acceptable variability within individual laboratories, we detect poor cross-site reproducibility of the differential gene expression signature between these two lines. Factor analy...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.stemcr.2018.08.013

Authors


Expand authors...
More from this funder
Grant:
Seventh Framework Program: 115439
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Reports Journal website
Volume:
11
Issue:
4
Pages:
897-911
Publication date:
2018-09-20
Acceptance date:
2018-08-21
DOI:
EISSN:
2213-6711
Pubs id:
pubs:921757
URN:
uri:d040c80d-73f8-4612-a8b2-2a2a29660fe9
UUID:
uuid:d040c80d-73f8-4612-a8b2-2a2a29660fe9
Local pid:
pubs:921757

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP