- Abstract:
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Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of the same two iPSC lines across five distinct laboratories. Despite uncovering acceptable variability within individual laboratories, we detect poor cross-site reproducibility of the differential gene expression signature between these two lines. Factor analy...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 5.2MB)
-
- Publisher copy:
- 10.1016/j.stemcr.2018.08.013
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Stem Cell Reports Journal website
- Volume:
- 11
- Issue:
- 4
- Pages:
- 897-911
- Publication date:
- 2018-09-20
- Acceptance date:
- 2018-08-21
- DOI:
- EISSN:
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2213-6711
- Pubs id:
-
pubs:921757
- URN:
-
uri:d040c80d-73f8-4612-a8b2-2a2a29660fe9
- UUID:
-
uuid:d040c80d-73f8-4612-a8b2-2a2a29660fe9
- Local pid:
- pubs:921757
- Copyright holder:
- Volpato et al
- Copyright date:
- 2018
- Notes:
-
© 2018 The Authors. This is an open access article under the CC BY-NC-ND
license
Journal article
Reproducibility of molecular phenotypes after long-term differentiation to human iPSC-derived neurons: A multi-site omics study
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