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Journal article : Review

Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers

Abstract:

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS) pathogenesis could be an important factor in the failure to identify disease-modifying therapy for this neurodegenerative disorder. Non-neuronal cells have crucial homeostatic functions within the CNS and evidence of involvement of these cells in the pathophysiology of several neurodegenerative disorders, including ALS, is accumulating. Microglia and astrocytes, in crosstalk with peripheral immune cells, can exert...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41582-021-00487-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0002-5159-5070
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Neurosciences
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0003-1063-3277
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Pharmacology
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0003-1380-6655
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Reviews Neurology Journal website
Volume:
17
Issue:
6
Pages:
333-348
Place of publication:
England
Publication date:
2021-04-29
Acceptance date:
2021-03-16
DOI:
EISSN:
1759-4766
ISSN:
1759-4758
Pmid:
33927394
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1174031
Local pid:
pubs:1174031
Deposit date:
2021-11-23

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