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Structure of human Aichi virus and implications for receptor binding

Abstract:

Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and reaches 90% later in life3,4. There is no available vaccine or effective antiviral treatment. Here, we describe the structure of AiV at 3.7 Å. This first high-resolution structure...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nmicrobiol.2016.150

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
ORCID:
0000-0003-4015-1404
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
ORCID:
0000-0002-4480-5439
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
ORCID:
0000-0002-0030-7235
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Funding agency for:
Ren, J
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Funding agency for:
Stuart, DI
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
1
Pages:
16150
Publication date:
2016-09-05
Acceptance date:
2016-07-21
DOI:
ISSN:
2058-5276
Pubs id:
pubs:641710
URN:
uri:cff9ca7d-90b1-48de-a794-db2258ec066a
UUID:
uuid:cff9ca7d-90b1-48de-a794-db2258ec066a
Local pid:
pubs:641710

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