Details of hydrophobic entanglement between small molecules and Braun’s lipoprotein within the cavity of the bacterial chaperone LolA

Journal article

Gram-negative bacteria possess an outer membrane (OM), a lipidic bilayer that surrounds a thin peptidoglycan (PG) layer and the cytoplasmic membrane (CM). The OM is an asymmetric bilayer whose outer leaflet is mainly composed by lipopolysaccharides (LPSs). LPS and PG have a direct role in antibacterial resistance and in the communication bacteria-host. There are many open questions on how the bacterial surface of pathogens and commensals interacts with the host in order to escape immune reco...

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Authors: Boags, A; Samsudin, F; Khalid, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Scientific Reports
• Volume: 9
• Issue: 1
• Pages: 3717-3717
• Publication date: 2019-03-06
• DOI: 10.1038/s41598-019-40170-z
• EISSN: 2045-2322
• ISSN: 2045-2322
• Language: English
• Keywords: Biochemistry; Crystallography; Molecule; Periplasmic space; Small molecule; Molecular dynamics; Chemistry; Membrane; Materials science; Computational chemistry; Biophysics; Biology; Gene; Cavity wall; Bacterial outer membrane; Vesicle; Escherichia coli; Umbrella sampling; Cell biology