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The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer.

Abstract:

The protective effect of early menopause shows that ovarian hormones increase the risk of breast cancer: it is likely that this is because they stimulate breast cell division. The mitotic rate of breast cells is higher during the luteal phase of the menstrual cycle than during the follicular phase, suggesting either that progesterone and oestrogen together induce more mitoses than oestrogen alone (the 'oestrogen plus progestagen hypothesis') or that oestrogen alone induces breast cell mitoses...

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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit
Role:
Author
Journal:
European journal of cancer and clinical oncology
Volume:
24
Issue:
1
Pages:
29-43
Publication date:
1988-01-05
DOI:
EISSN:
1878-5980
ISSN:
0277-5379
URN:
uuid:cfdff0ae-cdc1-42f5-8826-697b56153ba1
Source identifiers:
9477
Local pid:
pubs:9477

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