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Journal article

Clinical assessment determines the diagnosis of inclusion body myositis independently of pathological features.

Abstract:

BACKGROUND AND OBJECTIVE: Historically, the diagnosis of sporadic inclusion body myositis (IBM) has required the demonstration of the presence of a number of histopathological findings on muscle biopsy--namely, rimmed vacuoles, an inflammatory infiltrate with invasion of non-necrotic muscle fibres (partial invasion) and amyloid or 15-18 nm tubulofilamentous inclusions (Griggs criteria). However, biopsies of many patients with clinically typical IBM do not show all of these histopathological ...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp-2013-305690

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
84
Issue:
11
Pages:
1240-1246
Publication date:
2013-11-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:cfcd84e5-8a98-4025-9a49-6fb626758cd4
Source identifiers:
414428
Local pid:
pubs:414428

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