Journal article : Review
Mapping epigenetic modifications by sequencing technologies
- Abstract:
- The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biological processes as well as human diseases, including cancer. Precisely and quantitatively mapping over 100 [1], 17 [2], and 160 [3] different known types of epigenetic modifications in histone, DNA, and RNA is the key to understanding the role of epigenetic modifications in gene regulation in diverse biological processes. With the rapid development of sequencing technologies, scientists are able to detect specific epigenetic modifications with various quantitative, high-resolution, whole-genome/transcriptome approaches. Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1038/s41418-023-01213-1
Authors
- Publisher:
- Springer Nature
- Journal:
- Cell Death and Differentiation More from this journal
- Volume:
- 32
- Issue:
- 1
- Pages:
- 56-65
- Publication date:
- 2023-09-01
- Acceptance date:
- 2023-08-14
- DOI:
- EISSN:
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1476-5403
- ISSN:
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1350-9047
- Pmid:
-
37658169
- Language:
-
English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1519888
- Local pid:
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pubs:1519888
- Deposit date:
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2023-09-11
- ARK identifier:
Terms of use
- Copyright holder:
- Chen et al.
- Copyright date:
- 2023
- Rights statement:
- Copyright © 2023, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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