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The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Abstract:

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here, we defined the molecular and cellular mechanisms of this inflammation-mediated tissue priming. Re-exposure to inflammatory stimuli caused aggravated arthritis in rodent models. Tissue priming developed locally and independently of adaptive immunity. Repeatedly stimulated primed synovial fibroblasts (SFs) exhibited enhance...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.immuni.2021.03.003

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Publisher:
Cell Press Publisher's website
Journal:
Immunity Journal website
Volume:
54
Issue:
5
Pages:
1002-1021
Publication date:
2021-03-23
Acceptance date:
2021-03-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613

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