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Comparison of TGFβ expression in healthy and diseased human tendon

Abstract:

Introduction: Diseased tendons are characterised by fibrotic scar tissue, which adversely affects tendon structure and function and increases the likelihood of reinjury. The mechanisms and expression profiles of fibrosis in diseased tendon is understudied compared to pulmonary and renal tissues, where TGFβ and its associated superfamily are known to be key drivers of fibrosis and modulate extracellular matrix homeostasis. We hypothesised that differential expression of TGFβ superfamily member...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Funding agency for:
Dakin, SG
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Funding agency for:
Snelling, SB
NIHR Oxford Musculoskeletal Biomedical Research Unit More from this funder
Girdlestone Scholarship More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Arthritis Research and Therapy Journal website
Publication date:
2016-01-01
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:cf87477d-99c4-48e7-b8d0-5106604419ee
Source identifiers:
598588
Local pid:
pubs:598588

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