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Vascular endothelial growth factor, wild-type p53, and angiogenesis in early operable non-small cell lung cancer.

Abstract:

Vascular endothelial growth factor (VEGF) is a cytokine that is involved in tumor angiogenesis. Wild-type p53 (wt-p53) protein has been shown in cell lines to suppress angiogenesis through thrombospondin regulation. In this study, we immunohistochemically examined the expression of VEGF, nuclear and wild-type cytoplasmic p53, bcl-2, epidermal growth factor receptor, and c-erbB-2 oncoprotein; vascular grade; proliferation index; and extent of necrosis in non-small cell lung cancer (NSCLC). We ...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
4
Issue:
12
Pages:
3017-3024
Publication date:
1998-12-05
ISSN:
1078-0432
URN:
uuid:cf81ceda-302d-4936-8158-11fed444dbb1
Source identifiers:
486710
Local pid:
pubs:486710

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