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Journal article

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Abstract:

BACKGROUND: Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal. METHODS: The personalised anti-TNF therapy in Crohn's disease study (PANTS) is a prospective observational UK-wide study. We enrolled anti-TNF-naive patients (aged ≥6 years...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-4131-6792
More by this author
Role:
Author
ORCID:
0000-0002-5105-184X
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Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Contributor
Publisher:
Elsevier Publisher's website
Journal:
Lancet Gastroenterology and Hepatology Journal website
Volume:
4
Issue:
5
Pages:
341-353
Publication date:
2019-02-27
Acceptance date:
2018-12-18
DOI:
EISSN:
2468-1253
Pmid:
30824404
Source identifiers:
992651
Language:
English
Keywords:
Pubs id:
pubs:992651
UUID:
uuid:cf60cde7-8b93-48b2-8a85-f0d839cf2088
Local pid:
pubs:992651
Deposit date:
2019-11-20

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