Journal article

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Abstract:: BACKGROUND: Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal. METHODS: The personalised anti-TNF therapy in Crohn's disease study (PANTS) is a prospective observational UK-wide study. We enrolled anti-TNF-naive patients (aged ≥6 years...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Kennedy, N. A., Heap, G. A., Green, H. D., Hamilton, B., Bewshea, C., Walker, G. J., Thomas, A., Nice, R., Perry, M. H., Bouri, S., Chanchlani, N., Heerasing, N. M., Hendy, P., Lin, S., Gaya, D. R., Cummings, J. R. F., Selinger, C. P., Lees, C. W., Hart, A. L., … Russell, R. K. (2019). Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study. Lancet Gastroenterology and Hepatology, 4(5), 341–353.

MLA Style

Kennedy, NA, et al. “Predictors of Anti-TNF Treatment Failure in Anti-TNF-Naive Patients with Active Luminal Crohn's Disease: a Prospective, Multicentre, Cohort Study.” Lancet Gastroenterology and Hepatology, vol. 4, no. 5, 2019, pp. 341–53.

Chicago Style

Kennedy, NA, GA Heap, HD Green, et al. 2019. “Predictors of Anti-TNF Treatment Failure in Anti-TNF-Naive Patients with Active Luminal Crohn's Disease: a Prospective, Multicentre, Cohort Study.” Lancet Gastroenterology and Hepatology 4 (5): 341–53.
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Publisher copy:: 10.1016/s2468-1253(19)30012-3

Authors

+ Kennedy, NA More by this author

Role:: Author

+ Heap, GA More by this author

Role:: Author
ORCID:: 0000-0003-4131-6792

+ Green, HD More by this author

Role:: Author
ORCID:: 0000-0002-5105-184X

+ Hamilton, B More by this author

Role:: Author

+ Bewshea, C More by this author

Role:: Author

More authors...

Contributors

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: NDM Experimental Medicine
Role:: Contributor

+ Crohn's and Colitis UK More from this funder

Grant:: M11-2

+ Medical Research Council More from this funder

Grant:: MR/M00533X/1

Publisher:: Elsevier
Journal:: Lancet Gastroenterology and Hepatology More from this journal
Volume:: 4
Issue:: 5
Pages:: 341-353
Publication date:: 2019-02-27
Acceptance date:: 2018-12-18
DOI:: 10.1016/s2468-1253(19)30012-3
EISSN:: 2468-1253
Pmid:: 30824404

Language:: English
Keywords:: FFR
Pubs id:: pubs:992651
UUID:: uuid:cf60cde7-8b93-48b2-8a85-f0d839cf2088
Local pid:: pubs:992651
Source identifiers:: 992651
Deposit date:: 2019-11-20
ARK identifier:: ark:/29072/ora_cf60cde78b9348b28a85f0d839cf2088

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2019
Notes:: © 2019 Elsevier Ltd. All rights reserved.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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