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The effect of Indigenous American genomic ancestry on type 2 diabetes in Mexico: an analysis of 134 548 individuals from the Mexico City Prospective Study

Abstract:

Background: The prevalence of type 2 diabetes in Mexico is among the highest in the world and a major public health problem. The aim of this study was to examine the association between the percentage of Indigenous American genomic ancestry (AMR) and the prevalence of both prediabetes and type 2 diabetes in a large study of Mexican adults.

Methods: In this cross-sectional study, we analysed data from 134 548 individuals from the Mexico City Prospec...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2468-2667(25)00305-6

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author


More from this funder
Funder identifier:
https://ror.org/03x94j517
Grant:
MC_UU_00017/2
MR/Z504543/1


Publisher:
Elsevier
Journal:
Lancet Public Health More from this journal
Volume:
11
Issue:
2
Pages:
e111-e119
Publication date:
2026-02-01
Acceptance date:
2025-12-11
DOI:
EISSN:
2468-2667


Language:
English
Pubs id:
2349512
Local pid:
pubs:2349512
Deposit date:
2025-12-12
ARK identifier:

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