Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family

Journal article

Two closely related proteins, signal regulatory protein α (SIRPα; SHPS-1/CD172) and SIRPβ, have been described in humans. The existence of a third SIRP protein has been suggested by cDNA sequence only. We show that this third SIRP is a separate gene that is expressed as a protein with unique characteristics from both α and β genes and suggest that this gene should be termed SIRPγ. We have expressed the extracellular region of SIRPγ as a soluble protein and have shown that, like SIRPα, it bind...

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Authors: Brooke, G; Holbrook, J; Brown, M; Barclay, A

• Journal: Journal of Immunology
• Volume: 173
• Issue: 4
• Pages: 2562-2570
• Publication date: 2004-08-15
• ISSN: 0022-1767
• Language: English