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Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial

Abstract:

TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated.In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of TKM-130803 by intravenous infusion once daily for up to 7 d. On days when trial enrolment capacity was reached, patients were enrolled into a concurrent observational cohort. The primary outcome was survival to d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001997

Authors


Dunning, J More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
13
Issue:
4
Pages:
e1001997
Publication date:
2016-04-19
Acceptance date:
2016-03-08
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:cf33dd63-85ea-4762-8ebf-e412d406523d
Source identifiers:
616748
Local pid:
pubs:616748
Paper number:
4
Language:
English
Keywords:

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